Description
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Fentanyl Patch (also known as fentanil) is a potent, synthetic opioid pain medication with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors. Fentanyl is estimated to be between 50 and 100 times as potent as morphine.
it was first made by Paul Janssen in 1960,following the medical inception of pethidine (also known as meperidine, marketed as Demerol) several years earlier. Janssen developed it by assaying analogues of the structurally related drug pethidine for opioid activity. The widespread use of it triggered the production of it citrate (the salt formed by combining fentanyl and citric acid in a 1:1 stoichiometry), which entered medical use as a general anaesthetic under the trade name Sublimaze in the 1960s. Following this, many other it analogues were developed and introduced into medical practice, including sufentanil, alfentanil, remifentanil, and lofentanil.
it In the mid-1990s, fentanyl was introduced for palliative use with the it, followed in the next decade by the introduction of the fentanyl lollipop, dissolving tablets, and sublingual spray which are resorbed through the skin inside the mouth.As of 2012 it was the most widely used synthetic opioid in medicine.In 2013, 1700 kilograms were used globally.
it is also used as a recreational drug, and this use has led to thousands of overdose deaths each year in recent years. Deaths have also resulted from improper medical use. it has a relatively wide therapeutic index (270) which makes it a very safe surgical anesthetic when monitored carefully; however, its extreme potency requires careful measurements of highly diluted it in solution; attempting to accurately measure a dose of pure it is impractical without advanced scientific equipment as an effective dose and a lethal dose of it placed next to each other would be difficult or impossible to differentiate with the naked eye
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